Factors associated with a lower response rate to therapy:
(1) Ann Arbor Stage IV
(2) high-intermediate or high risk International Prognostic Index (IPI)
(3) elevated LDH level
Factors associated with poor survival:
(1) ECOG performance scale >= 2
(2) splenomegaly
(3) B-symptoms (fever, night sweats, weight loss)
(4) mitotic index > 2.5 mitoses per high powered field (hpf)
(5) leukocyte count > 10,000 per µL (associated with leukemic MCL)
(6) elevated LDH level (above the upper limit of normal)
(7) blastic cytology
(8) high-intermediate or high risk International Prognostic Index
where:
• The IPI includes age, ECOG status, Stage, serum LDH and extranodal involvement.
