Arcaini et al identified prognostic risk factors for marginal zone lymphomas using multivariate analysis. Many patients have an indolent course but some patients may pursue a more aggressive course and benefit from more aggressive therapy. The authors are from the University of Pavia and the Hospital of Placenza in Italy.
Splenic Marginal Zone Lymphoma
Parameter
Overall Survival
Event Free Survival
age
age > 60 years
hemoglobin
hemoglobin <= 11 g/dL
hemoglobin <= 11 g/dL
albumin
albumin <= 3.5 g/dL
extent beyond local lymph nodes and bone marrow
dissemination to peripheral lymph nodes
Nodal Marginal Zone Lymphoma
Parameter
Overall Survival
age
age > 60 years
hemoglobin
hemoglobin <= 11 g/dL
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