In patients with intermediate or high grade lymphoma, clinical or laboratory factors associated with prognosis can be identified using univariate or multivariate analysis. These can help in making therapeutic decisions, especially if the histologic type is unfavorable.
Prognostic Factors Including Remission Status
Variable
Favorable
remission status
complete remission
LDH
low value
clinical stage (Ann Arbor)
stage I
serum albumin
high value (>= 4 g/dL)
Prognostic Factors, Excluding Remission Status
Variable
Favorable
clinical stage (Ann Arbor)
stage I
albumin
high value (>= 4 g/dL)
age
young age (< 50 years)
GGT
low value
B category symptoms
absent
Interpretation
Attainment of complete remission was the best predictor of overall survival.
(1) median survival for complete responders: over 6 years (good)
(2) median survival for partial responders: 13 months (intermediate)
(3) median survival for nonresponders: 2 months (poor)
If the remission status was excluded, the clinical stage was the most significant pretreatment prognostic indicator.
Patients with no favorable indicators may benefit from more aggressive therapy.
To read more or access our algorithms and calculators, please log in or register.
