The largest cities are amazing collections of human beings. They also face enormous problems ("mega mess").
Problems affecting the largest urban areas:
(1) sewage
(2) garbage
(3) air quality
(4) crime
(5) safe water
(6) food supply
(7) poverty
(8) affordability
(9) infectious disease and control of epidemic disease
(10) healthcare
(11) human services
(12) disaster management
(13) construction
(14) transportation and means of access
(15) electricity and other utilities
Factors impacting these problems:
(1) wealth and resources
(2) urban planning
(3) industrialization
(4) proximity to hazards (earthquakes, hurricanes, volcanoes, etc)
(5) weather
(6) societal norms and social integration
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Specialty: Emergency Medicine, Critical Care