The probability that a patient will have the clinical findings of dementia with Lewy bodies (DLD) can be predicted from the Lewy body count and Braak Stage.
Parameters:
(1) stage of Braak and Braak for Alzheimer's Disease (Stage 0 to Stage VI)
(2) category of McKeith at al for Lewy body distribution from the 1996 Consensus conference (see previous section)
Lewy Body Category
Braak Stage
Probability of Clinical Syndrome
brain stem predominant
0, I or II
low
brain stem predominant
III or IV
low
brain stem predominant
V or VI
low
limbic
0, I or II
high
limbic
III or IV
intermediate
limbic
V or VI
low
neocortical
0, I or II
high
neocortical
III or IV
high
neocortical
V or VI
intermediate
Patterns shown:
(1) The higher the Braak score the greater the risk of clinical Alzheimer's Disease.
(2) The more diffuse the Lewy body distribution the greater the risk of clinical DLB.
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