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Primary Systemic Amyloidosis Early Mortality Risk Score

Purpose: To evaluate a patient with primary systemic amyloidosis.

Description

Kumar et al developed an Early Mortality Risk Score for evaluating patients with primary systemic amyloidosis. A patient at increased risk for early mortality may benefit from more aggressive management. The authors are from the Mayo Clinic.


Patient selection: primary systemic amyloidosis

 

Outcome: mortality within 1 year (early mortality)

 

Parameters:

(1) serum troponin in µg/L (Roche Diagnostics)

(2) serum N-terminal pro-BNP (brain natriuretic peptide) in ng/L (Roche Diagnostics)

(3) serum uric acid in mg/dL (Roche Diagnostics)

 

Parameter

Finding

Points

serum troponin

<= 0.01 µg/L

0

 

> 0.01 µg/L

1

serum N-terminal pro-BNP

<= 4,200 ng/L

0

 

> 4,200 ng/L

1

serum uric acid

<= 8.0 mg/dL

0

 

> 8.0 mg/dL

1

 

where:

• A serum uric acid had a reference range of 4.3 to 8.0 mg/dL for men and postmenopausal women and 2.3-6.0 mg/dL for premenopausal women.

• The reference range for serum troponin was not given.

• The reference range for N-terminal pro-BNP was not given.

• The testing was referred to as baseline and not from time of clinical onset or diagnosis.

 

total score =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 3

• The higher the score the greater the risk of 1 year mortality.

 

Risk Score

1-Year Mortality Rate

0

12%

1

24%

2

46%

3

69%

 


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Specialty

Objective

ICD-10