Pregabalin (Lyrica) has significant renal excretion and its dose should be adjusted in a patient with renal impairment.
Parameters:
(1) estimated creatinine clearance in mL per min
(2) daily dose of pregabalin in mg per day
(3) hemodialysis
Standard daily doses:
(1) 150 mg/day
(2) 300 mg/day
(3) 450 mg/day
(4) 600 mg/day
|
Creatinine Clearance |
Percent of Daily Dose |
|
>= 60 mL per min |
100% |
|
30 to 59 |
50% |
|
15 to 29 |
25% |
|
< 15 mL per min |
12.5% |
The minimum dose per day was 25 mg.
|
Creatinine Clearance |
Dosage Regimens |
|
>= 60 mL per min |
bid or tid |
|
30 to 59 |
bid or tid |
|
15 to 29 |
qd or bid |
|
< 15 mL per min |
qd |
A supplemental dose is given following the hemodialysis session.
|
Daily Dose in End-Stage Renal Failure |
Supplemental Dose After Hemodialysis |
|
25 mg |
25 or 50 mg |
|
25 to 50 mg |
50 or 75 mg |
|
50 to 75 mg |
75 or 100 mg |
|
75 mg |
100 or 150 mg |
Specialty: Toxicology, Emergency Medicine, Critical Care, Nephrology
ICD-10: ,
