medical decision support medical decision support
Sign In

Predictors of da Silva et al for Adverse Drug Effects in a Patient Treated with Benznidazole for Chaga's Disease (Trypanosoma cruzi)

Description

da Silva et identified factors that are predictive of adverse drug effects in a patient being treated with benznidazole for Chaga's disease (Trypanosoma cruzi). These can help to identify a patient who may benefit from closer management or who may have to discontinue therapy. The authors are from the Evandro Chagas National Institute of Infectious Diseases. Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.


 

Patient selection: >= 13 years of age with Chaga's disease treated with benznidazole.

 

Outcome: adverse drug reaction

 

Parameter:

(1) gender

(2) education

(3) race

(4) age

Parameter

Finding

Odds Ratio

gender

Male

1

 

Female

2.9

education

did not complete elementary school

1

 

completed elementary school

2

race

Black

1

 

White

5

 

Mulatto

5.7

age in years

13 to 19 years

1

 

20 to 40 years

2.5

 

> 40 years

1

 

cumulative odds ratio for overall ADR =

= PRODUCT(all 4 parameters)

 

Interpretation:

• minimum cumulative odds rato: 1

• maximum cumulative odds ratio: 82.7

 

Performance:

• The area under the ROC curve is 0.71.

 


To read more or access our algorithms and calculators, please log in or register.

Specialty