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Predictors of Coppo et al for Outcome in a Patient with Henoch-Schonlein Nephritis

Description

Coppo et al evaluated outcomes for children and adults with Henoch-Schonlein nephritis. They identified factors predicting a worse outcome for these patients. The authors are from Reina Margherita Hospital (Torino), Alessandro Manzoni Hospital (Lecco) and Ospedale degli Infermi (Rimini) in Italy.


 

Endpoints: creatinine doubling and need for dialysis

 

Risk factors for disease progression:

(1) female gender

(2) adult age

(3) level of proteinuria (increase in odds ratio of 1.8 for each increase in 1 g/d for adults)

Proteinuria

Child

Adult

minimal

<= 10 mg/kg/d

<= 1 g/d

moderate

10.1 to 50 mg/kg/d

1.1 to 3.5 g/d

nephrotic

> 50 mg/kg/d

> 3.5 g/d

 


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