Subjects: mean age 62 with 25% >= 75 years of age with 85% in the ICU
Risk factors for mortality from multivariable proportional hazards regression analysis:
(1) male gender
(2) acute myocardial infarction (AMI)
(3) oliguria (average urine output < 400 mL per day at time of entry)
(4) acute stroke or seizure
(5) mechanical ventilation
(6) metabolic acidosis
(7) chronic immunosuppression
(8) hyperbilirubinemia (relative risk increased by 1.06 per 1 mg/dL increase)
where:
• Hypoalbuminemia had a p value 0.08 in the model.
• In a multivariable logistic regression analysis, the first 6 items were significant. In addition, a history of hypertension was associated with a reduced risk of mortality.
• A total serum bilirubin of 11 mg/dL to reach a relative risk of 1.9, comparable to mechanical ventilation.
• Most of the risk factors reflect an organ failure.
