Hirschsprung's disease may occur as a familial disorder. A person closely related to someone with Hirschsprung's disease may be at risk for developing the disease. The risk can be predicted based on the type of disease involvement, the familial relationship and the genders of the people involved.
Short Segment Hirschsprung's Disease in Proband
Female Inquirer
Male Inquirer
sib of affected male
1%
4%
sib of affected female
2%
6%
offspring of affected male
close to 0%
close to 0%
offspring of affected female
close to 0%
close to 0%
Colonic Segment Hirschsprung's Disease in Proband
Female Inquirer
Male Inquirer
sib of affected male
7%
10%
sib of affected female
10%
13%
offspring of affected male
9%
11%
offspring of affected female
11%
15%
Long Segment Hirschsprung's Disease in Proband
Female Inquirer
Male Inquirer
sib of affected male
8%
11%
sib of affected female
18%
23%
offspring of affected male
13%
18%
offspring of affected female
22%
28%
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