Agarwal et al developed 2 semen quality scores for evaluating men with infertility. This uses parameters determined by computer assisted semen analysis. The authors are from The Cleveland Clinic Foundation.
Parameters:
(1) sperm concentration as a multiple of 10^6 per mL
(2) percent motility (from 0 to 100)
(3) percent normal using strict morphology using Tygerberg criteria (Mortimer and Menkveld, from 0 to 100)
(4) percent normal using WHO morphology (from 0 to 100)
(5) curvilinear velocity in micrometers per second (µm/s)
(6) straight line velocity in micrometers per second (µm/s)
(7) average path velocity in micrometers per second (µm/s)
(8) linearity in percent (enter from 0 to 100)
(9) amplitude of lateral head displacement in micrometers (µm)
where:
• The curvilinear velocity is the time-averaged velocity of the sperm head along its actual curvilinear path.
• The straight line velocity is the time-averaged velocity of the sperm head along the straight line between its first detected position and its last.
• The average path velocity is the time-averaged velocity of the sperm head along its average path.
• The linearity of curvilinear path = (VSL) / (VCL) * 100%
• The amplitude of lateral head displacement is magnitude of lateral displacement of a sperm head about its average path.
overall semen quality SQ score =
= (((0.807647 * (LOG10(sperm concentration + 1))) + (0.254114 * (LOG10(percent motility + 1))) + (0.331027 * (LOG10(percent normal Tygerberg + 1))) + (0.274769 * (LOG10(percent normal WHO + 1))) + (0.146286 * (LOG10(curvilinear velocity + 1))) + (0.193481 * (LOG10(straight line velocity + 1))) + (0.175990 * (LOG10(average path velocity + 1))) + (0.009109 * (LOG10(linearity + 1))) + (0.090307 * (LOG10(amplitude of lateral head displacement + 1)))) * 34.46018) - 20.1911369
relative semen quality RQ score =
= (((-0.567457 * (LOG10(sperm concentration + 1))) + (0.147947* (LOG10(percent motility + 1))) + (0.605335 * (LOG10(percent normal Tygerberg + 1))) + (0.418694 * (LOG10(percent normal WHO + 1))) + (0.180399 * (LOG10(curvilinear velocity + 1))) + (0.202853 * (LOG10(straight line velocity + 1))) + (0.1891590 * (LOG10(average path velocity + 1))) + (0.009502 * (LOG10(linearity + 1))) + (0.069321 * (LOG10(amplitude of lateral head displacement + 1)))) * 55.1448) + 24.5183708
where:
• A "1" was added to all of the raw values (page 344). The arguments given escape me.
• 34.46018 = 10 / (0.29019)
• 55.1448 = 10 / (0.1813407)
Interpretation:
• The SQ score is the sum of all semen characteristics with varying weights for each parameter. The SQ score decreases as the number of abnormal features increases.
• The SQ score for a normal person ranges from 100 to 120.
• The RQ score is the relative quality, with negative weighting for concentration and positive weighting for the other 8 parameters. The highest RQ score would be for a specimen with a low sperm concentration and the other features above average.
• The RQ score for a normal person ranges from 100 to 120.
• The scores from before and after an intervention can be compared to determine if an improvement has occurred.
Specialty: Urology, Clinical Laboratory
ICD-10: ,