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Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score (NAS) of Kleiner et al

Purpose: To evaluate a liver biopsy from a patient to determine the activity of nonalcoholic fatty liver disease (NAFLD) using the NAD score of Kleiner et al.

Description

Kleiner et al developed a score for grading histologic features in a patient with nonalcoholic fatty liver disease. The authors are from the Nonalcoholic Steatohepatitis Clinical Research Network.


Parameters:

(1) steatosis

(2) lobular inflammation

(3) ballooning

 

Parameter

Finding

Points

steatosis

none

0

 

mild

1

 

moderate

2

 

severe

3

lobular inflammation

none

0

 

mild

1

 

moderate

2

 

severe

3

ballooning

none

0

 

mild to moderate

1

 

marked

2

 

total activity score =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 8

• The higher the score the more likely steatohepatitis is present.

 

Activity Score

Diagnosis

0, 1 or 2

not steatohepatitis

3 or 4

indeterminate

5 to 8

steatohepatitis

 


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Specialty

Objective

ICD-10