Risk Factors for Non-Hodgkin's Lymphoma in Patient with HIV Infection

 

Parameters:

(1) age of the patient in years at entry to the cohort

(2) CD4 and CD8 lymphocyte counts

(3) antiretroviral therapy

 

Age of the patient at entry to the cohort: An age > 39 years was associated with decreased risk of developing lymphoma. The relative ratio decreases 1.02 for each year > 39 years (relative ratio = (-1.02 * ((age in years) - 39))

 

CD4 and CD* cell counts: The pattern of CD4 <= 200 per µL and CD8 < 595 per µL is associated with increased risk, with a relative ratio of 1.3.

 

Antiretroviral therapy:

(1) No antiretroviral therapy was associated with the greatest risk.

(2) Treatment with nucleoside analogues alone was associated with increased risk.

(3) A regimen that included a protease inhibitor (PI) and/or non-nucleoside reverse transcriptase inhibitor (NNRTI) showed a lower risk.

 

An HIV-positive patient with risk factors should be monitored more closely for development of malignant lymphoma. Ideally they should be treated with PI and/or NNRTI.