Features:
(1) resident at high altitude
(2) neurologic signs and symptoms
(3) centrifugal resolution of symptoms if the patient stays at a low altitude
(4) exclusion of other causes for peripheral neuropathy (toxic, nutritional, diabetes, etc.)
Most common neurologic signs and symptoms:
(1) migraine-like headache
(2) burning or tingling paresthesias in feet and/or hands
Variable neurologic signs and symptoms:
(1) dizziness
(2) depression or loss of distal reflexes
(3) impaired distal sensation in hands and/or feet
(4) ataxia on clinical examination
Biopsy of a peripheral nerve shows a mild demyelinating neuropathy.
