Therapy with mycophenolate mofetil has been associated with colitis.
Patient selection: transplant patient being treated with mycophenolate mofetil
Presentation: diarrhea with weight loss and variable decrease in renal function
Diagnosis:
(1) The patient has the onset of colitis after starting therapy with mycophenolate mofetil.
(2) The colitis may be segmental or a pancolitis.
(3) A colon biopsy shows a colitis resembling ischemic colitis or graft-vs-host disease.
(4) Discontinuing the mycophenolate therapy is followed by resolution of the colitis.
(5) Other causes of colitis (ischemia, GVHD, CMV, etc) are excluded.
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Specialty: Gastroenterology, Pharmacology, clinical
ICD-10: ,
