Warfarin Daily Dose Calculator Based on Genotypic Analysis of CYP2C9 and VKORC1

Purpose: To determine a patient's daily warfarin dose based on physical and genotypic findings based on the models of Sconce et al.

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Evaluation

Are you trying to determine a patient's daily warfarin dose?

Yes

Age of the patient

years

Body height

Select an appropriate answer for each finding

Number of CYP2C9*2 alleles

Number of CYP2C9*3 alleles

VKORC1 genotype

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Value of X1

Warfarin dose based on age

Value of X2

Warfarin dose based on CYP2C9 *2 and *3

Value of X3

Warfarin dose based on VKORC1

Value of X4

Warfarin dose based on height

Value of X5

Warfarin dose based on all variables

Caution: A qualified health practitioner should verify all results.
Keep patient data confidential and comply with all legal requirements.

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
- Risk Factors of Hylek et al for Excessive Warfarin Anticoagulation
- Algorithm of Dunn for the Perioperative Management of a Patient Receiving Oral Anticoagulation
Clinical Diagnosis, Including Family History For Genetics
- Warfarin (Coumadin) Resistance Testing
- Warfarin Resistance Associated with Poor Intestinal Absorption
Laboratory Tests
- Warfarin (Coumadin) Resistance Testing

Therapy

Selection
- Algorithm of Dunn for the Perioperative Management of a Patient Receiving Oral Anticoagulation
Pharmacogenetics
- Regression Model of Wells et al for Predicting Warfarin Dose Using Pharmacogenetics
Drug Interactions
- Daily Warfarin Dosage Adjustment for Patient Receiving Long-Term Amiodarone Therapy
Dosage Calculations
Dosage Adjustments
Failure Handling And Therapy Escalation

Monitoring

Response To Therapy
- Warfarin (Coumadin) Resistance Testing
Adverse Effects
- Risk Factors of Hylek et al for Excessive Warfarin Anticoagulation
Drug Levels
- Warfarin (Coumadin) Resistance Testing
Overdose And Reversal
- Warfarin (Coumadin) Resistance Testing
- Risk Factors of Hylek et al for Excessive Warfarin Anticoagulation

Specialty

Hematology Oncology
Clinical Laboratory
Pharmacology, clinical

Objective

dosage calculations

ICD-10

I74 - Arterial embolism and thrombosis
I80 - Phlebitis and thrombophlebitis
I81 - Portal vein thrombosis
I82 - Other venous embolism and thrombosis
O88 - Obstetric embolism
T79.0 - Air embolism (traumatic)
T79.1 - Fat embolism (traumatic)

Info

Purpose: To determine a patient's daily warfarin dose based on physical and genotypic findings based on the models of Sconce et al.

Specialty: Hematology Oncology, Clinical Laboratory, Pharmacology, clinical

Objective: dosage calculations

ICD-10: I74, I80, I81, I82, O88, T79.0, T79.1,

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