Model of Meanwell et al for Predicting Encephalopathy in a Patient Receiving Combination Chemotherapy with Ifosfamide and Mesna

 

Patient selection: cancer chemotherapy with ifosfamide and mesna

 

Parameters:

(1) serum albumin in g/L

(2) serum creatinine in µmol/L

(3) pelvic lesion (0 if absent, 1 if present)

 

S1 =

= (1.1650 * (albumin)) + (0.1527 * (creatinine)) + (5.2841 * (points for pelvic lesion)) - 31.3381

 

S2

= (0.8398 * (albumin)) + (0.2055 * (creatinine)) + (7.1589 * (points for pelvic lesion)) - 28.5367

 

probability of Grade 0 to 2 CNS toxicity =

= 1 / (1 + EXP((S2)-(S1))