Patient selection: diffuse large B-cell lymphoma
Outcome: event-free survival at 24 months(EFS24)
Parameters
(1) diameter in centimeters (bulky disease)
(2) ECOG performance status
(3) normalized serum LDH in IU/L
(4) stage
(5) absolute lymphocyte count (ALC)
(6) gender
(7) age in years
normalized LDH =
= (serum LDH) / (upper limit of the normal reference range)
points for absolute lymphocyte count =
= MAX(0,(-12.5 * ((absolute count)/1000) + 25)
|
Parameter
|
Findings
|
Points
|
|
diameter in cm
|
< 10 cm
|
0
|
|
|
>= 10 cm ("bulky")
|
15.2
|
|
ECOG performance
|
0 or 1
|
0
|
|
|
2, 3 or 4
|
19.6
|
|
stage
|
I
|
0
|
|
|
II
|
3.6
|
|
|
III
|
8.8
|
|
|
IV
|
23.7
|
|
gender
|
Female
|
0
|
|
|
Male
|
14.3
|
|
Normalized LDH
|
Points
|
|
<= 0.5
|
0
|
|
0.5 to 1.3
|
(30.87 * ((ratio)^2)) + (3.95 * (ratio)) - 11.23
|
|
1.31 to 5
|
(14.66 * (ratio)) + 25.59
|
|
> 5
|
100
|
|
Age
|
Points
|
|
< 70
|
0
|
|
70 to 85
|
(3.286 * (age)) - 230.3
|
|
> 85
|
49.1
|
total score =
= SUM(points for all 7 parameters)
Interpretation:
• minimum score 0
• maximum score: 250
• The higher the score the lower the chances of event-free survival at 24 months.
• The higher the IPI24 score and the IPI the less likely that the patient will be event-free at 24 months.
X =
= (0.01659 * (total score)) - 1.954
IPI24 score =
= 1 / (1 + EXP((-1) * X))
