Ways to minimize chemotherapy-associated hair loss:
(1) If possible select an effective regimen that is associated with less hair loss.
(2) Consider the use of a scalp cooling device (to around 5°C) during chemotherapy.
(3) Minimize trauma to the hair during and after chemotherapy.
(4) Have a plan for handling different degrees of hair loss, either by camouflaging loss or covering the scalp.
(5) Have a plan for handling different degrees of patient distress evoked by the hair loss.
(6) Apply minoxidil (2% or 5%) to the scalp after chemotherapy is complete to enhance hair regrowth, minimizing the period of reduced hair.
Scalp cooling:
(1) Reports about its effectiveness vary and some studies have been poorly designed or have not controlled all variables.
(2) There is a theoretical concern that it may reduce the effectiveness of chemotherapy on malignant cells that may be in the scalp or scalp blood vessels.
Topical minoxidil:
(1) It does not prevent hair loss during chemotherapy.
(2) A 5% solution may be more effective than the 2% solution but it may be associated with more skin reactions.
