The Methotrexate Intolerance Severity Score (MISS) is used to evaluate a patient for gastrointestinal toxicity associated with methotrexate therapy.
Anticipatory symptoms refer to symptoms that occur just before taking a dose.
Associative symptoms refer to symptoms that occur when thinking about taking a dose.
Symptoms:
(1) abdominal pain after methotrexate
(2) abdominal pain, anticipatory
(3) abdominal pain, associative
(4) nausea after methotrexate
(5) nausea, anticipatory
(6) nausea associative
(7) vomiting after methotrexate
(8) vomiting, anticipatory
(9) vomiting, associative
(10) oral pain (sore mouth) after methotrexate
(11) oral pain, anticipatory
(12) oral pain, associative
(13) behavioral. restlessness
(14) behavioiral, crying
(15) behavioral, irritability
(16) behavioral, refusal of methotrexate
Symptoms |
Points |
none |
0 |
mild |
1 |
moderate |
2 |
severe |
3 |
total score =
= SUM(points for all 16 findings)
Interpretation:
• minimum score: 0
• maximum score: 48
• A score >= 6 is considered positive.
Specialty: Gastroenterology, Pharmacology, clinical