Method of Sawchuk and Zaske for Dosing an Aminoglycoside: Estimating the Volume of Distribution

Once the elimination rate constant is known, the volume of distribution for the aminoglycoside can be calculated.

volume of distribution =

= ((dose) * (A) / (time for infusion) / (elimination rate constant) / (B))

A =

= (1 - (EXP((-1) * (elimination rate constant) * (time for infusion)))) =

= "accumulation index"

B =

= ((C(max-ss)) - (C(0) * (EXP((-1) * (elimination rate constant) * (time for infusion)))))

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