Infarction is most often described in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) but may occur in Hodgkin's disease or other types of malignant lymphoma.
Diagnosis of infarction associated with a malignant lymphoma:
(1) Presence of lymph node infarction.
(2) Evidence of malignant lymphoma.
(3) Exclusion of other causes of lymph node infarction (infection, thrombosis, trauma, etc).
The diagnosis of malignant lymphoma may involve:
(1) biopsy of another lymph node
(2) any non-infarcted tissue in the lymph node
(3) immunohistochemical markers (provided false positive and false negative results can be avoided)
(4) evidence of diagnostic genetic mutations
