Liver Failure Acetaminophen | Medical Algorithm

The probability of death following acetaminophen poisoning can be estimated from clinical and laboratory data.

Parameters:

(1) grade of encephalopathy

(2) prothrombin time

(3) serum creatinine

(4) white blood cell count

(5) serum potassium

Parameter	Value
grade of encephalopathy	2.248 * (grade of encephalopathy)
prothrombin time	0.0117 * (prothrombin time in seconds)
serum creatinine	0.0064 * (serum creatinine in µmol/L)
white blood cell count	0.045 * (WBC count as 10^9/L)
serum potassium	0 if potassium <= 5.5 mmol/L; 1.4623 if potassium > 5.5 mmol/L

X =

= SUM(points for all of the parameters) - 13.241

If the equation is rearranged:

probability of death =

= 1 / (1 + EXP((-1) * X))

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Probability of Fatal Outcome in Fulminant Hepatic Failure due to Acetaminophen