Drug that is injected into subcutaneous tissue or intramuscularly may leak out afterwards. This may or may not be significant.
Risk factors for leakage:
(1) intramuscular injection (increased tissue pressures)
(2) scarring at the injection site
(3) injection technique
Significance of the leakage depends on:
(1) mechanism: local scar tissue could be associated with impaired absorption
(2) volume of injection fluid that seeps out
(3) therapeutic range for the drug
Differential diagnosis:
(1) leakage of interstitial fluid
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Specialty: Toxicology, Emergency Medicine, Critical Care
ICD-10: ,
