Time of exposure resulting in malformations: any time after the 15th day following conception
Organs affected by malformations:
(1) craniofacial
(2) cardiac
(3) central nervous system
(4) thymic
(5) musculoskeletal
Craniofacial malformations:
(1) microtia and/or anotia (small or absent external ear)
(2) stenosis of the external ear canal
(3) facial nerve paralysis
(4) accessory parietal sutures
(5) micrognathia
(6) depressed nasal bridge
(7) ocular hypertelorism
(8) cleft palate
Cardiac malformations:
(1) hypoplastic left ventricle
(2) interrupted aortic arch
(3) ventricular septal defect
(4) conotruncal malformations (transposition of the great vessels, tetralogy of Fallot, truncus arteriosus)
(5) atrial septal defects
Central nervous system malformations:
(1) hydrocephalus
(2) microcephaly
(3) cerebellar hypoplasia
(4) cerebellar microdysgenesis
(5) mental retardation or behavioral disturbances
(6) spina bifida
(7) optic nerve blindness
(8) retinal defects
(9) microphthalmia
Thymic malformations:
(1) hypoplasia or aplasia
(2) dysplasia
(3) ectopia
Musculoskeletal malformations:
(1) limb hypoplasia
(2) decreased muscle tone
Accutane can also result in stillbirths or spontaneous abortions.
