Description

Acute lymphoblastic leukemia (ALL) may or may not involve the central nervous system (CNS). A blood CSF tap can make the diagnosis of CNS involvement more difficult.


 

Situation – all of the following:

(1) The patient has leukemic cells in the peripheral blood.

(2) The CSF tap was bloody.

(3) The CSF WBC count is >= 5 per µL.

(4) Lymphoblasts are present in the CSF.

 

Parameters:

(1) white blood cell count of the CSF

(2) red blood cell count of the CSF

(3) white blood cell count in the peripheral blood

(4) red blood cell count in the peripheral blood

 

ratio of WBC to RBC in CSF =

= (white blood cell count in CSF) / (red blood cell count in the CSF)

 

ratio of WBC to RBC in peripheral blood =

= (white blood cell count in blood) / (red blood cell count in the blood)

 

ratio of cells in the CSF to ratio of cells in peripheral blood =

= (white blood cell count in CSF) * (red blood cell count in blood) / ((white blood cell count in blood) * (red blood cell count in CSF))

 

Ratio of CSF to Blood

Designation

< 2

CNS-2

>= 2

CNS-3

 


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