| To identify a patient with a lupus anticoagulant whose oral anticoagulation therapy should be monitored by an alternative method to the PT and INR.|
|Cardiovascular Diseases, Vascular Medicine, Clinical Pharmacology, Pharmaceutical Medicine|
|laboratory tests, failure handling and therapy escalation|
|I74, I81, I82, M32, O88|
Moll and Ortel identified problems with the use of the prothrombin time (PT) and International Normalized Ratio (INR) for monitoring warfarin therapy in a patient with a lupus anticoagulant. Warfarin therapy in these patients should be monitored with an alternative method, since the PT may be unreliable. The authors are from Duke University.