Chromosome analysis may be performed in both partners seeking assisted fertilization if certain indications are present. This usually involves karyotyping although other techniques may be used when warranted.
Indications for chromosome analysis of partners seeking assisted fertilization:
(1) repeated miscarriage in the patients or among relatives
(2) previous stillbirth, especially when malformations are present or the cause of fetal death is unclear
(3) history of malformations or other congenital disorders in the patients or their relatives
(4) other couples in the family with infertility
(5) planned micro-assisted fertilization
Notes:
(1) Be sure to inquire about previous marriages or relationships.
(2) Some of the techniques of micro-assisted fertilization are recent, and the risk for increased malformations or congenital anomalies may be more theoretical than real.
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