Flibanserin (Addyi) may be carefully helpful in selected women with decreased sexual desire. It is only prescribed by certified physicians.
Indication for use: premenopausal woman with hypoactive sexual desire disorder (HSDD).
It is not indicated for:
(1) postmenopausal women
(2) other disorders of depressed libido in women
(3) enhancement of sexual performance
Contraindications:
(1) use with alcohol
(2) hepatic dysfunction
(3) significant inhibition of cytochrome P450 3A4 (CYP3A4) – ketoconazole, grapefruit juice, etc
(4) poor CYP2C19 metabolizer
An agent that induces CYP3A4 causes reduced flibanserin effect.
Adverse effects may include:
(1) severe hypotension
(2) syncope
(3) central nervous system (CNS) depression
(4) digoxin toxicity if taking digoxin
(5) nausea
(6) fatigue
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Specialty: Obstetrics & Gynecology
