Griseofulvin is poorly soluble in water, which limits gastrointestinal absorption following an oral dose. Absorption can often be improved if certain steps are taken.
Factor
Intervention
poor drug dissolution secondary to particle size
ultramicronize the drug into tiny particles
poor absorption on an empty stomach
take with food, especially a fatty meal
poor water solubility
mixture with polyethylene glycol or preparation of micelles
poor absorption of a large dose
take a smaller dose more often (but this may make compliance a problem)
interference due to concurrent barbiturate therapy
avoid barbiturates while taking griseovulvin
Some patients are poor absorbers of griseofulvin despite all interventions.
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