Good described a combined immunodeficiency state in 1954 affecting patients with thymoma.
Features of Good's syndrome include:
(1) presence of a thymoma
(2) acquired B and T cell immunodeficiency
(3) opportunistic infections
Organisms causing opportunistic infections:
(1) encapsulated bacteria (Haemophilus influenzae, Streptococcus pneumoniae)
(2) Salmonella, Campylobacter
(3) Staphylococcus aurues
(4) mucocutaneous Candidiasis
(5) cytomegalovirus (CMV) or Herpes simplex
(6) Pneumocystis jirovecii (nee carinii)
(7) Giardia
Laboratory findings:
(1) hypogammaglobulinemia
(2) CD4 T-cell lymphopenia
The patient may also experience other autoimmune paraneoplastic disorders:
(1) pure red cell aplasia
(2) autoimmune enteropathy
(3) myasthenia
(4) oral lichen planus
(5) polyarthropathy
(6) dermatomyositis
