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Identification of a Patient with a Hereditary Deficiency of Prekallikrein and/or High Molecular Weight Kininogen

Purpose:

To evaluate a patient with a prolonged aPTT for evidence of a hereditary deficiency of prekallikrein and/or high molecular weight kininogen.

Specialty:

Hematology, Hematology

Objective:

laboratory tests, criteria for diagnosis

ICD-10:

D68.8

Description:

Prekallikrein, high molecular weight kininogen and Factor XII are the contact factors involved in initiation of coagulation. Deficiencies of prekallikrein and/or high molecular weight kininogen are rare.

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