Hodgkin's Disease | Pediatric Patient | Risk Factors for Hypothyroidism

 

Time to onset of hypothyroidism ranged from 0.7 to 11.3 years with the median interval 2.9 years.

 

Parameters affecting risk of hypothyroidism:

(1) race

(2) gender

(3) dose of radiation to the thyroid in Gy

 

Risk factors for hypothyroidism:

(1) white race (hazard ratio 2.5 vs 1.0 for Blacks)

(2) female gender (hazard ratio 1.4 for female vs 1.0 for males)

(3) radiation dose > 21 Gy (hazard ratio 16.7 vs 7.0 for dose <= 21 Gy vs 1.0 for none)

Race	Radiation Dose	Cumulative HR	Hypothyroid
white	> 21 Gy	42	65%
white	<= 21 Gy	17.5	36% (*)
black	> 21 Gy	17	36%
black	<= 21 Gy	7	12% (*)
black	none	1	1.5% (*)

 

where:

• The percent hypothyroid is the 20-year estimated cumulative incidence.

• The (*) values are inferred from the cumulative HR and the other values (see page 1518).