Wongso et al developed a simple score for predicting the risk of treatment-related mortality (TRM) for a patient with advanced stage Hodgkin disease. The authors are from the German Hodgkin Study Group.
Patient selection: advanced stage Hodgkin disease with ECOG performance 0 to 2
Treatment: escalated dose BEACOPP
Most common cause of death: neutropenic infections
Parameters:
(1) age of the patient in years
(2) ECOG performance status (or comparable Karnofsky Performance Scale)
|
Parameter |
Finding |
Points |
|
age in years |
< 40 years of age |
0 |
|
|
40 to 49 years of age |
1 |
|
|
>= 50 years of age |
2 |
|
ECOG performance status |
0 or 1 |
0 |
|
|
2 |
1 |
total score =
= SUM(points for the 2 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the greater the treatment-related mortality.
|
Score |
5-Year Survival |
|
0 |
96% |
|
1 |
94% |
|
2 |
80% |
|
3 |
60% |
Purpose: To identify a patient with advanced stage Hodgkin disease who is at risk for treatment-related mortality using the score of Wongso et al.
Specialty: Hematology Oncology
Objective: criteria for diagnosis, severity, prognosis, stage, response to therapy, adverse effects
ICD-10: C81.9, C85.9,
