Features of non-Hodgkin lymphomas with Hodgkin-like cells:
(1) cells are positive for CD15 and/or CD30
(2) cells are negative for B cell markers (CD20. PAX5, etc)
(3) other features of Hodgkin's disease are absent
(4) presence of a B or T cell lymphoproliferative disorder
(5) exclusion of alternative explanations
Hodgkin-like cells:
(1) have nucleoli that tend to be small and multiple
(2) can occur in clusters or sheets
(3) may infiltrate sinusoids
Some cases with Hodgkin-like cells may be associated with Epstein-Barr virus (EBV).
Differential diagnosis:
(1) composite lymphoma (mixed Hodgkins and non-Hodgkins lymphoma)
