The atypical lymphocytes seen in Mycosis fungoides are T cells with scant cytoplasm and hyperchromatic, convoluted ("cerebriform") nuclei.
Histologic features seen in mycosis fungoides:
(1) multiple Pautrier microaggregates
(2) diffuse infiltration with individual atypical lymphocytes into the epidermis
(3) a few small intraepidermal clusters of a few atypical lymphocytes
(4) a few individual intraepidermal atypical lymphocytes
(5) dense upper dermal bandlike interface infiltrate that includes atypical lymphocytes
(6) mild to moderate polymorphous upper dermal infiltrate that includes atypical lymphocytes and has a focal interface pattern
(7) extension of the infiltrate into the deep dermis
Diagnostic of mycosis fungoides - one or more of the following:
(1) feature 1
(2) feature 2
(3) feature 3, 4 and 5
(4) feature 3, 4, 6 and 7
Consistent with mycosis fungoides - one or more of the following:
(1) feature 3 and 5
(2) feature 3 and 6
(3) feature 4 and 5
(4) feature 4, 6 and 7
Suggestive of mycosis fungoides - one or more of the following:
(1) feature 3
(2) feature 4
(3) feature 5
(4) feature 6
