Mookerjee et al graded cholestatic change in liver biopsies from patient’s with alcoholic liver disease (ALD). The authors are from the Royal Free Hospital, University of Graz, University College London Hospital and the Medical University of Graz, Austria.
Patient selection: alcoholic liver disease
Criteria for adequate liver biopsy:
(1) >= 5 portal tracts
(2) length >= 10 mm
Parameters:
(1) bile plugs in canaliculi
(2) bile plugs in bile ductules
(3) cholangiolitis (neutrophils in and around lumen of ductules)
|
Parameters |
Finding |
Points |
|
bile plugs in canaliculi |
none |
0 |
|
|
1 to 5 |
1 |
|
|
6 to 10 |
2 |
|
|
11 to 20 |
3 |
|
|
> 20 |
4 |
|
bile plugs in ductules |
none |
0 |
|
|
1 |
1 |
|
|
2 |
2 |
|
|
3 |
3 |
|
|
> 3 |
4 |
|
cholangiolitis |
absent |
0 |
|
|
present |
1 |
where:
• The viewing area for these findings was not stated. Scoring was semiquantitative. It may be based on a high-power field (40x objective).
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 9
• The higher the score the greater the cholestasis.
Specialty: Gastroenterology, Toxicology
ICD-10: ,
