Mao et al listed criteria for response to therapy for chronic HBeAg-positive viral hepatitis B (HBV). The authors are from Xiamen University in Fujian Province, China.
Patient selection: HBeAg-positive HBV
Therapy: interferon-alpha
Parameters:
(1) serum ALT
(2) blood HBV DNA
(3) HBeAg
Serum ALT |
HBV DNA |
HBeAg |
Response |
normal |
undetectable |
negative |
complete |
normal |
detectable at < 10^5 copies/mL |
negative or positive |
partial |
any other |
any other |
any other |
non-response |
A complete or partial response is considered sustained if still present at 24 weeks after cessation of therapy.
If the patient had a response but abnormal findings returned after treatment stopped then it is a relapse (or reinfection).
Purpose: To evaluate the response to therapy shown by a patient with a chronic HBeAg-positive hepatitis B viral (HBV) infection.
Specialty: Infectious Diseases, Pharmacology, clinical, Gastroenterology
Objective: pharmacogenetics, dosage calculations
ICD-10: B16, B18.0, B18.1,