Key clinical features:
(HA) hyperandrogenism
(IR) insulin resistance, with increased serum insulin levels
(AN) acanthosis nigricans
Features of hyperandrogenism may include:
(1) acne
(2) alopecia
(3) hirsutism
(4) variable clitorimegaly
(5) amenorrhea
(6) infertility
(7) increased muscularity
Additional findings:
(1) obesity with increased ratio of waist-to-hips
(2) association with endocrine disorders including:
(2a) polycystic ovary syndrome
(2b) adrenal disorders(Cushing's syndrome, congenital adrenal hyperplasia, adrenocortical tumor)
(2c) thyroid disorders (Hashimoto's thyroiditis, Graves disease)
(2d) pituitary disorders (adenoma with acromegaly, other)
