Parameters:
(1) eosinophilia
(2) lymphocyte depletion
(3) atypia in Reed-Sternberg (RS) cells
Eosinophilia consists of one or both of the following:
(1) clusters of eosinophils in >= 5 high power fields. or
(2) eosinophils > 5% of all cells
Atypia in Reed Sternberg cells:
(1) anaplastic and bizarre appearing
(2) pleomorphic nuclear features
(3) nuclear hyperchromatism
(4) highly irregular nuclear features
|
Parameter
|
Finding
|
Points
|
|
eosinophilia
|
absent
|
0
|
|
|
present
|
1
|
|
lymphocyte depletion
|
>= 33% of all cells present
|
0
|
|
|
< 33%
|
1
|
|
atypia in RS cells
|
<= 25%
|
0
|
|
|
> 25%
|
1
|
number of risk factors present =
= SUM(points for all 3 factors)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 3
• A low risk group was defined as no (0) risk factors, while high risk had >= 1.
|
Total Score
|
Risk Group
|
Overall Survival at 9 Years
|
|
0
|
low
|
90%
|
|
1 to 3
|
high
|
67%
|
from Figure 3, page 4066
