Both Mycosis Fungoides and Sezary Syndrome are T-cell lymphomas with cutaneous deposits that may involve lymph nodes. The extent of lymph node involvement can be determined on histologic examination.
General features:
(1) dermatopathic lymphadenopathy (expansion of paracortical zone with dendritic cells, macrophages with or without melanin, lymphocytes, plasma cells, and variable numbers of eosinophils)
(2) number of T-cells with cerebriform (convoluted) nuclei
(3) effacement of nodal architecture
Dermatopathic Lymphadenopathy |
Malignant T-Cells |
Nodal Architecture |
Grade |
variable |
none |
normal |
LN-0 |
present |
occasional, without clusters |
normal |
LN-1 |
present |
small clusters |
normal |
LN-2 |
variable |
numerous, may be in large clusters |
may be partial effacement |
LN-3 |
variable |
numerous, diffuse |
partial to complete effacement |
LN-4 |
Specialty: Hematology Oncology, Dermatology
ICD-10: ,