Przybelski et al reported a grading scheme for adverse reactions to a blood substitute. These are similar to the Clinical Toxicity Criteria (CTC) used for chemotherapy. The authors are from Baxter Healthcare Corporation.
Patient selection: status post infusion of a blood substitute
Allergic measures:
(1) drug fever
(2) rash
(3) bronchospasm
(4) anaphylaxis
Allergic Reaction
Finding
Grade
drug fever
none
0
< 38°C (< 100.4°F)
1
>= 38°C
2
rash
none
0
transient
1
urticaria
2
serum sickness
3
bronchospasm
none
0
mild
2
requires parenteral therapy
3
anaphylaxis
absent
0
present
4
where:
• A very high drug fever would seem to be Grade 3.
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