An anaphylactoid reaction is an acute reaction that resembles anaphylaxis but which does not involve IgE antibodies. Laxenaire graded the severity of an anaphylactoid reaction based on clinical signs and symptoms.
Parameters:
(1) cutaneous findings
(2) cardiovascular findings
(3) respiratory findings
Cutaneous
Cardiovascular
Respiratory
Grade
none
none
none
0
generalized erythema, urticaria, angioedema
none
none
I
generalized erythema, urticaria, angioedema
mild hypotension, tachycardia
cough, mild dyspnea
II
NA
collapse, severe tachy- or bradycardia, serious arrhythmias
bronchospasm, severe dyspnea
III
NA
cardiac arrest
respiratory arrest
IV
death
V
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