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Follicular Lymphoma International Prognostic Index 2 (FLIPI2)

Purpose: To evaluate a patient with a newly diagnosed follicular lymphoma using the Follicular Lymphoma International Prognostic Index 2 (FLIPI2).

Description

Federico et al reported the Follicular Lymphoma International Prognostic Index 2 (FLIPI2). This help determine the prognosis for a patient with a follicular lymphoma. It was developed members of the the International Follicular Lymphoma Prognostic Factor Project.


 

Patient selection: newly diagnosed follicular lymphoma

 

Parameters:

(1) age of the patient in years

(2) maximum diameter of the largest affected lymph node in cm

(3) serum beta-2 microglobulin level

(4) hemoglobin

(5) bone marrow involvement

 

Parameter

Finding

Points

age of the patient in years

<= 60 years

0

 

> 60 years

1

maximum diameter of the largest lymph node

<= 6 cm

0

 

> 6 cm

1

serum beta-2 microglobulin

normal

0

 

elevated (above the upper limit of normal)

1

hemoglobin

>= 12 g/dL

0

 

< 12 g/dL

1

bone marrow involvement

absent

0

 

present

1

 

where:

• The original FLIPI shares age and hemoglobin with FLIPI2.

• The original FLIPI used serum LDH, Ann Arbor stage and number of involved sites.

 

FLIP2 score =

= SUM(points for the 5 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the worse the prognosis.

 

FLIPI2 Score

Risk Group

3 Year Overall Survival

0

low

99%

1 or 2

intermediate

96%

3, 4 or 5

high

84%

 


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Specialty

Objective

ICD-10