The Food and Drug Administration (FDA) has developed grading scales for reactions to vaccines during clinical trials. One of these scales deals with changes in basic chemical tests.
Patient selection: renal reaction after the vaccination
Basic chemistry tests include:
(1) serum sodium in mEq/L
(2) serum potassium in mEq/L
(3) serum glucose in mg/dL
(4) serum calcium in mg/dL
(5) serum magnesium in mg/dL (hypomagnesemia)
(6) serum phosphorus in mg/dL (hypophosphatemia)
Serum BUN and creatinine are included in renal assessment.
Reduced urine output is not included as a measure.
|
Reaction |
Grade |
|
None |
0 |
|
Mild |
1 |
|
moderate |
2 |
|
severe |
3 |
|
potentially life threatening |
4 |
|
Renal Parameter |
Finding |
Grade |
|
serum sodium |
> 150 mEq/L |
4 |
|
|
148 to 150 mEq/L |
3 |
|
|
146 to 147 mEq/L |
2 |
|
|
144 to 145 mEq/L |
1 |
|
|
135 to 143 mEq/L |
0 |
|
|
132 to 134 mEq/L |
1 |
|
|
130 to 131 mEq/L |
2 |
|
|
125 to 129 mEq/L |
3 |
|
|
< 125 mEq/L |
4 |
|
serum potassium |
> 5.6 mEq/L |
4 |
|
|
5.5 to 5.6 mEq/L |
3 |
|
|
5.3 to 5.4 mEq/L |
2 |
|
|
5.1 to 5.2 mEq/L |
1 |
|
|
3.7 to 5.0 mEq/L |
0 |
|
|
3.5 to 3.6 mEq/L |
1 |
|
|
3.3 to 3.4 mEq/L |
2 |
|
|
3.1 to 3.2 mEq/L |
3 |
|
|
< 3.1 mEq/L |
4 |
|
serum glucose (fasting) |
insulin required or hyperomsolar coma |
4 |
|
|
> 125 mg/dL |
3 |
|
|
111 to 125 mg/dL |
2 |
|
|
100 to 110mg/dL |
1 |
|
|
70 to 99 mg/dL |
0 |
|
|
65 to 69 mg/dL |
1 |
|
|
55 to 64 mg/dL |
2 |
|
|
45 to 54 mg/dL |
3 |
|
|
< 45 mg/dL |
4 |
|
serum calcium |
> 12.0 mg/dL |
4 |
|
|
11.6 to 12 mg/dL |
3 |
|
|
11.1 to 11.5 mg/dL |
2 |
|
|
10.5 to 11.0 mg/dL |
1 |
|
|
8.5 yo 10.4 mg/dL |
0 |
|
|
8.0 to 8.4 mg/dL |
1 |
|
|
7.5 to 7.9 mg/dL |
2 |
|
|
7.0 to 7.4 mg/dL |
3 |
|
|
< 7.0 mg/dL |
4 |
|
serum magnesium |
> 1.5 mg/dL |
0 |
|
|
1.3 to 1.5 mg/dL |
1 |
|
|
1.1 to 1.2 mg/dL |
2 |
|
|
0.9 to 1.0 mg/dL |
3 |
|
|
< 0.9 mg/dL |
4 |
InfoSpecialty: Infectious Diseases, Pharmacology, clinical |
