Yoshida et al identified a number of factors predicting whether a child with aplastic anemia will respond to immunosuppressive therapy. The authors are from multiple hospitals in Japan.
Patient selection: pediatric patient with moderate or severe aplastic anemia, excluding congenital aplastic anemia and paroxysmal nocturnal hemoglobinuria (PNH)
Immunosuppressive therapy consists of antithymocyte globulin (ATC), cyclosporine and granulocyte colony stimulating factor.
Parameters:
(1) white blood cell count
(2) gender
(3) interval from diagnosis to initiation of immunosuppressive therapy
Parameter
Finding
Points
WBC count
>= 2,000 per µL
0
< 2,000 per µL
1
gender
female
0
male
1
time interval
< 30 days
1
>= 30 days
0
total number of factors predicting response to immunosuppressive therapy =
= SUM(points for all 3 parameters)
Interpretation:
• minimum number of factors predicting response: 0
• maximum number of factors predicting response: 3
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