Quijano et al identified factors indicative of leptomeningeal involvement in a patient with Burkitt’s lymphoma. These can help to identify a patient who should undergo additional testing to confirm the diagnosis. The authors are from multiple universities in Spain.
Parameters:
(1) neurologic symptoms
(2) serum beta-2 microglobulin concentration
Parameters
Finding
Points
neurologic symptoms
absent
0
present
1
serum beta-2 microglobulin
normal
0
elevated
1
total score =
= SUM(points for the 2 parameters)
Interpretation:
• minimum score: 0
• maximum score: 2
• A score of 2 is specific for leptomeningeal involvement (100%).
• A score of 1 is suspicious for leptomeningeal disease (50% chance)
• Flow cytometry of the cerebrospinal fluid (CSF) is the most accurate of establishing the diagnosis of leptomeningeal disease.
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