Linderkamp et al derived equations for estimating the blood volume in infants and children <= 14 years of age. The lowest error in prediction was found with ones based multiple regression equation relating the logarithm of blood volume to combined height and logarithm of the weight.
Patient selection:
(1) 160 infants and children from 1 hour to 14 years of age from Germany
(2) Patients were excluded if they had a disease affecting blood volume, plasma volume or red blood cell mass.
(3) Newborn infants had early cord clamping.
NOTE: Lean body mass is better than actual weight for measuring blood volume in children.
|
Age |
Gender |
Blood Volume in mL/kg |
|---|---|---|
|
0 - 1 day |
|
81.9 +/- 8.6 |
|
2 - 30 days |
|
84.4 +/- 7.5 |
|
1 - 2 months |
|
79.4 +/- 6.9 |
|
3 - 6 months |
|
76.6 +/- 9.0 |
|
7 - 12 months |
|
82.4 +/- 10.4 |
|
13 - 24 months |
|
86.1 +/- 9.7 |
|
2 -3 years |
M |
80.5 +/- 8.7 |
|
|
F |
79.0 +/- 7.3 |
|
4 - 6 years |
M |
76.7 +/- 6.3 |
|
|
F |
77.4 +/- 4.3 |
|
7 - 10 years |
M |
79.6 +/- 7.1 |
|
|
F |
72.7 +/- 6.2 |
|
11 -14 years |
M |
74.4 +/- 5.2 |
|
|
F |
68.3+/- 3.5 |
Table 1, page 228
Group I: Infants and Children < 2 Years of Age
LOG10 (blood volume in mL) =
= (0.7891 * (LOG10(body weight in kilograms))) + (0.004132 * (height in cm)) + 1.8117
error: 10.1%
Group II: Boys Aged 2-14 years, and Girls Aged 2-6 Years
LOG10 (blood volume in mL) =
= (0.6459 * (LOG10(body weight in kilograms))) + (0.002743 * (height in cm)) + 2.0324
error: 4.8%
Group III: Girls Aged 7-14 Years
LOG10 (blood volume in mL) =
= (0.6412 * (LOG10(body weight in kilograms))) + (0.001270 * (height in cm)) + 2.2169
error: 7.5%
Additional Equations Using a Single Body Size Measure
(Table 2, page 229)
|
Group |
Equation |
r value |
% error |
|---|---|---|---|
|
I |
blood volume in mL = (84.9 * (body weight in kilograms)) - 10 |
0.963 |
11.8% |
|
|
blood volume in mL = (20.3 * (height in cm)) - 772 |
0.950 |
11.6% |
|
|
blood volume in mL = (2,147 * (BSA in square meters)) - 179 |
0.964 |
12.2% |
|
|
log10 (blood volume in mL) = (0.019550 * (height in cm)) + 1.4162 |
0.944 |
16.9% |
|
|
log10 (blood volume in mL) = (0.9795 * (log10(weight in kilograms))) + 1.9318 |
0.974 |
10.9% |
|
|
log10 (blood volume in mL) = (2.7862 * (log10(height in cm))) - 2.3427 |
0.955 |
14.2% |
|
|
log10 (blood volume in mL) = (1.4062 * (log10(BSA in square meters))) + 3.3846 |
0.973 |
11.9% |
|
II |
blood volume in mL = (73.9 * (body weight in kilograms)) + 73 |
0.983 |
5.1% |
|
|
blood volume in mL = (36.9 * (height in cm)) - 2580 |
0.945 |
5.9% |
|
|
blood volume in mL = (2,916 * (BSA in square meters)) - 761 |
0.979 |
4.8% |
|
|
log10 (blood volume in mL) = (0.008070 * (height in cm)) + 2.2537 |
0.974 |
6.5% |
|
|
log10 (blood volume in mL) = (0.9699 * (log10(weight in kilograms))) + 1.9278 |
0.978 |
5.5% |
|
|
log10 (blood volume in mL) = (2.2461* (log10(height in cm))) - 1.4277 |
0.963 |
6.7% |
|
|
log10 (blood volume in mL) = (1.3656 * (log10(BSA in square meters))) + 3.3190 |
0.985 |
4.6% |
|
III |
blood volume in mL = (53.8 * (body weight in kilograms)) + 552 |
0.954 |
8.4% |
|
|
blood volume in mL = (37.2 * (height in cm)) - 2851 |
0.932 |
17.6% |
|
|
blood volume in mL = (2,478 * (BSA in square meters)) - 488 |
0.969 |
9.6% |
|
|
log10 (blood volume in mL) = (0.006867 * (height in cm)) + 2.4048 |
0.949 |
9.3% |
|
|
log10 (blood volume in mL) = (0.7790* (log10(weight in kilograms))) + 2.1852 |
0.958 |
7.9% |
|
|
log10 (blood volume in mL) = (2.1843 * (log10(height in cm))) - 1.3188 |
0.940 |
10.9% |
|
|
log10 (blood volume in mL) = (1.1984 * (log10(BSA in square meters))) + 3.2990 |
0.971 |
7.9% |
percent error from Table 4, page 231
Purpose: To calculate the blood volume of infants or children <= 14 years of age using the regression equations of Linderkamp et al.
Objective: other testing
ICD-10: Z51.3,
