Blood may not be an optimum specimen if a body has started to decompose. Felby et al developed a number of equations for correlating ketone body levels in the cerebrospinal fluid (CSF) and vitreous humor (VH) with blood levels. The authors are from the University of South Denmark.
Analytes:
(1) total ketone bodies in µmol/L
(2) acetoacetate in µmol/L
(3) beta-hydroxybutyrate in µmol/L
Fluid
Analyte
LOG10(blood concentration for analyte in µmol/L) =
CSF
TKB
-0.13739 + (1.07242 * LOG10(TKB CSF))
CSF
AA
0.2634 + (0.86269 * LOG10(AA CSF))
CSF
BHB
-0.39046 + (1.22068 * LOG10(BHB CSF))
vitreous
TKB
0.21951 + (0.86870 * LOG10(TKB VH))
vitreous
AA
0.38446 + (0.81748 * LOG10(AA VH))
vitreous
BHB
0.10810 + (0.86504 * LOG10(BHB VH))
blood concentration of the analyte in µmol/L =
= 10^(equation for each fluid and analyte)
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